Effects of Neuraxial Anaesthesia
Neuraxial Anaesthesia
- Epidural and spinal anaesthesia both produce similar inhibition of autonomic thermoregulatory responses
Effects on Sensors and Central Processing by Hypothalamus
- Decrease threshold to trigger vasoconstriction and shivering by 0.6C
- Reduction in threshold is proportional to the number of spinal segments blocked
- Effects are result of local actions on spinal cord and not due to systemic recirculation of local anaesthetic (iv administration of lignocaine has no thermoregulatory effect)
- Mechanism
- Thermal input from lower limbs is dominated by tonic signals from cold thermoreceptors
- Regional anaesthesia blocks these cold signals
- Brain interprets the decrease input as relative leg warming →
↓
threshold that triggers vasoconstriction and shivering
Effect on Effector Mechanisms
- Impairs vasoconstriction and shivering at the blocked spinal levels
- Hence, once triggered, thermoregulatory mechanisms are less effective
Pattern of Hypothermia
Phase 1
- Similar to GA, rapid reduction in core temperature, resulting from redistribution of heat from core to periphery
- Usually, not quite as severe (0.5 - 1C)
Phase 2
- Similar to GA, heat loss >
heat production
Phase 3
- Unlike GA, core temp does not necessarily plateau
- Vasoconstriction in the lower limbs - which constitute the bulk of the peripheral thermal compartment - is impaired and metabolic heat cannot be constrained to the core thermal compartment
Combined Spinal and General Anaesthesia
- The threshold to trigger vasoconstriction is 1C lower than with GA alone
- Prevents plateau in core temperature in Phase 3